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Title 

Magnone A and B, novel Anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii

Authors 

Keun Young JungDong Seon KimSei Ryang OhSi Hyung ParkIm Seon LeeJung Joon LeeDong Hyuk ShinHyeong Kyu Lee

Publisher 

American Chemical Society

Issue Date 

1998

Citation 

Journal of Natural Products, vol. 61, no. 0, pp. 808-811

Keywords 

ginkgolide bmagnone amagnone bthrombocyte activating factorthrombocyte activating factor receptor affecting agentunclassified drugcarbon nuclear magnetic resonanceconcentration responsedrug antagonismdrug isolation

Abstract 

In a search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the Chinese crude drug shin-i, the flower buds of Magnolia fargesii. Their structures were elucidated as (2S,3R,4R)- tetrahydro-2-(3,4-dimethoxyphenyl)-4-(3,4-dimethoxybenzoyl)-3- (hydroxymethyl)furan (magnone A, 1) and (2S,3R,4R)-tetrahydro-2-(3,4,5- trimethoxyphenyl)-4-(3,4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone B, 2). Magnones A and B showed antagonistic activity against PAF in the [3H]PAF receptor binding assay with the IC50 values of 3.8 x 10-5 M and 2.7 x 10-5 M, respectively.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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