상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

Authors 

S H JungH S LeeJ S SongHwan Mook KimSang Bae HanChang Woo LeeM S LeeD R ChoiJ A LeeY H ChungS J YoonEun Yi MoonH S HwangS K SeongD K Lee

Publisher 

Elsevier

Issue Date 

1998

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 8, no. 12, pp. 1547-1550

Keywords 

dw 2143antineoplastic activitydrug synthesisstructure activity relationdrug screening assays, antitumor

Abstract 

Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

ISSN 

0960-894X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)