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Title 

Phospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba

Authors 

Ji Suk LeeYou Sun ChoEun Jung ParkJin Woong KimWon Keun OhHyun Sun LeeJong Seog Ahn

Publisher 

American Chemical Society

Issue Date 

1998

Citation 

Journal of Natural Products, vol. 61, no. 7, pp. 867-871

Keywords 

ginkgo biloba extractGinkgo biloba

Abstract 

Ten phenolic compounds were isolated from the CHCl3 extract of Ginkgo biloba sarcotestas (Ginkgoaceae) as a new class of phosphatidylinositol- specific phospholipase Cγ1 (PI-PLCγ1) inhibitors. The substances without the long chain were ineffective: On the other hand, the activities of these compounds were dramatically decreased by acetylation of aromatic hydroxyl groups of cardanol, phenolic acid, and bilobol and by methylation of the aromatic carboxyl group of phenolic acid. The unsaturated long chain as well as the aromatic hydroxyl and carboxyl groups might play a key role for the PI-PLCγ1 inhibitory activity. These compounds also inhibited the growth of a number of human cancer cell lines, but were less cytotoxic against a human normal colon cell line.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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