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Title 

Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase

Authors 

Jae Yoon LeemHo Yong ParkHidesuke FukazawaYoshimasa UeharaShunji Natori

Publisher 

Pharmaceutical Society of Japan

Issue Date 

1998

Citation 

Biological & Pharmaceutical Bulletin, vol. 21, no. 7, pp. 784-785

Keywords 

5-S-GADantibacterial substanceinsect immunityinhibition of PTKsP60(v-src)P210(BCR-ABL)

Abstract 

We examined the inhibitory effects of N-β-alanyl-5-S-glutathionyl-3,4- dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. We found that 5-S-GAD directly inhibited not only tyrosine phosphorylation of PTK p60(v-src), but also tyrosine phosphorylation of PTK p210(BCR-ABL). The inhibitory potency of 5-S-GAD was comparable to that of radicicol and herbimycin A of PTK inhibitor.

ISSN 

0918-6158

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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