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Title 

Chaetoglobosin A, an inhibitor of Bleb formation on K562 cells induced by phorbol 12,13-dibutyrate

Authors 

Hack Ryong KoBo Yeon KimSoon Cheol AhnWon Keun OhJin Hee KimHyun Sun LeeHwan Mook KimSang Bae HanTae Ick MheenJong Seog Ahn

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

1998

Citation 

Journal of Microbiology and Biotechnology, vol. 8, no. 6, pp. 705-709

Keywords 

Bleb formationinhibitorPDBuK562 cellschaetoglobosin A

Abstract 

In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12,13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the IC50 value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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