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Title 

Biological activities of sesquiterpene lactones isolated from several compositae plants. Part 1 Cytotoxicity against cancer cell lines

 

수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제1보) 암세포주에 대한 세포독성

Authors 

Dae Sik JangKi Hun ParkHwan Mook KimDong Ho HongHyo Kon ChunYung Hee KhoMin Suk Yang

Publisher 

Korean Society of Pharmacognosy

Issue Date 

1998

Citation 

Korean Journal of Pharmacognosy, vol. 29, no. 3, pp. 243-247

Keywords 

CompositaeHemisteptia lyrataChrysanthemum zawadskiiChrysanthemum borealesesquiterpene lactonecytotoxicity

Abstract 

A diverse panel of human tumor cell lines and a mouse melanoma cell line (B16-F1) were used for the cytotoxicity test of the nine sesquiterpene lactones with α-methylene-γ-lactone group isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale. In the cell adhesion inhibitory activity test against B16-F1 mouse melanoma cell, hemistepcin B, cumambrin B, costunolide and tulipinolide were shown significant activities with IC50 range of 2.2, 4.1, 0.9 and 0.3 μg/ml, respectively. In the cytotoxicity test against human tumor cells, the most active compound was costunolide having IC50 values of below 0.3 μg/ml against all the tested cell lines except for UACC62. Cumambrin A, hendelin and costunolide exhibited more strong activity against HCT15 and UO-31 cell lines than a positive control, adriamycin. All tested compounds showed an IC50 values of below 5.0 μg/ml against all the tested cell lines.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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