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Title 

Anticomplementary activity of stilbenes from medicinal plants

Authors 

Sei Ryang OhShi Yong RyuSi Hyung ParkKeun Young JungIm Seon LeeKyung Seop AhnJung Joon LeeHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1998

Citation 

Archives of Pharmacal Research, vol. 21, no. 6, pp. 703-706

Keywords 

anticomplementary activityStilbenesResveratrolOxyresveratrol3,5-Dihydroxy-4-methoxystilbeneRhapontigeninRhaponticinPiceid2,3,4′,5-Tetrahydroxy stilbene-2-O-β-glucoside2,3,4′,5-Tetrahydroxystilbene-2--glucosyl-4'-O-β-gluco-side

Abstract 

The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4′-methoxystilbene (3) was most potent with IC50 value of 1.5×10-4 M followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4′,5-tetrahydroxystilbene-2-O-β-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4′ of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2′ of 1 or C-3′ of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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