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Title 

Anti-complement activity of tiliroside from the flower buds of magnolia fargesii

Authors 

Keun Young JungSei Ryang OhSi Hyung ParkIm Seon LeeKyung Seop AhnJung Joon LeeHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

1998

Citation 

Biological & Pharmaceutical Bulletin, vol. 21, no. 10, pp. 1077-1078

Keywords 

Magnolia fargesiitilirosideanticomplementary activity

Abstract 

As part of the search for anticomplementary active components from natural products, the anticomplementary properties of methanolic extracts from the flower buds of Magnolia fargesii have been investigated. Bioassay- guided chromatographic Separation of the active constituents led to the isolation of compound 1, whose structure was identified by spectroscopic methods to be kaempferol 3-O-β-D-(6-O-coumaroyl)glucopyranoside (tiliroside). Tiliroside showed very potent anti-complement activity (IC50=5.4x 10-5 M) on the classical pathway of the complement system, even higher than rosmarinic acid, which is a well-known inhibitor against the complement system. On the other hand, the hydrolysates of tiliroside, kaempferol, astragalin and p-coumaric acid showed very weak activity on this system.

ISSN 

0918-6158

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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