상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Roles of acetyl-CoA carboxylase β in muscle cell differentiation and in mitochondrial fatty acid oxidation

Authors 

Jung Kee LeeKi Han Kim

Publisher 

Elsevier

Issue Date 

1999

Citation 

Biochemical and Biophysical Research Communications, vol. 254, no. 0, pp. 657-660

Keywords 

acetyl coenzyme a carboxylaseAcetyl-CoA Carboxylaseanimal cellcell differentiationcell fusionfatty acidfatty acid oxidationmuscle cellmuscle mitochondrion

Abstract 

Acetyl-CoA carboxylase β is expressed primarily in heart and skeletal muscle, where it may play a role in the control of mitochondrial fatty acid uptake and oxidation by controlling carnitine-palmitoyl-CoA transferase 1. To investigate the relationship between ACC-β expression and myoblast differentiation, we specifically blocked ACC-β production by expressing an antisense gene to the specific N-terminal region of ACC-β in H9c2 cells. The expression of the antisense ACC-β mRNA retarded cell fusion, myosin formation, and creatine kinase induction; all of these parameters are hallmarks of muscle cell differentiation. On the other hand, the rate of fatty acid oxidation was not affected by the presence or absence of ACC-β in the cells.

ISSN 

0006-291X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)