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Title 

Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

Authors 

Kyung Seop AhnMoon Sun HahmEun Jin ParkHyeong Kyu LeeIk Hwan Kim

Publisher 

Georg Thieme Verlag

Issue Date 

1998

Citation 

Planta Medica, vol. 64, no. 0, pp. 468-470

Keywords 

corosolic acidcrataegus extractcytotoxic agentprotein kinase c inhibitorstaurosporineunclassified drugursolic acidbreast carcinomacancer cellcontrolled study

Abstract 

Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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