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Title 

Acyl-CoA:cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species

Authors 

Byoung-Mog KwonHyun Ju JungJung Hee LimYoun Soo KimMi Kyung KimYoung Kook KimSong Hae BokKi Hwan BaeIhn Rhan Lee

Publisher 

Georg Thieme Verlag

Issue Date 

1999

Citation 

Planta Medica, vol. 65, no. 0, pp. 74-76

Keywords 

cholesterol acyltransferasecholesterol acyltransferase inhibitorhypocholesterolemic agentenzyme activityhypercholesterolemia

Abstract 

Fifteen lignans were isolated from the fruits of Schizandra chinensis, the leaves of Machilus thunbergii, and the flower buds of Magnolia denudata. They were identified as gomisins, schizandrin, wuweizisu, schizantherin, licarins, and machilin, which inhibited rat liver ACAT with IC50 values of 25-200 μM. Gomisin N is the most potent inhibitor with IC50 value of 25 μM in these lignans.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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