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Title 

A nucleoside with lipid peroxidation inhibitory activity from Agrocybe cylindracea

 

버들송이로부터 분리한 Nucleoside계 화합물의 지질과산화 저해활성

Authors 

In Kyoung LeeBong Sik YunIck Dong Yoo

Publisher 

Korean Journal of Applied Microbiology and Biotechnology

Issue Date 

1998

Citation 

Korean Journal of Applied Microbiology & Biotechnology, vol. 26, no. 6, pp. 558-561

Keywords 

Agrocybe cylindracea5'-deoxy-5'-methylthioadenosinemushroomNMRlipid peroxidation inhibitor

Abstract 

In the screening for lipid peroxidation inhibitors from edible mushroom, Agrocybe cylindracea, a bioactive compound AG 8 was isolated. The AG 8 was purified from methanol extract of its fruit body by Diaion HP-20 column chromatography, ethyl acetate extraction, and silica gel column chromatography, consecutively. Based on various NMR studies including 1H irradiation and HMBC experiments, the AG 8 was identified as MTA, 5'-deoxy- 5'-methylthioadenosine. This compound inhibited lipid peroxidation with an IC50 value of 3.2 μg/ml. The MTA was isolated for the first time from basidiomycetes.

ISSN 

0257-2389

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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