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Title 

A mannofucogalactan, fomitellan A, with mitogneic effect from fruit bodies of Fomitella fraxinea (Imaz.)

Authors 

Soo Muk ChoHiroyuki KoshinoSeung Hun YuIck Dong Yoo

Publisher 

Elsevier

Issue Date 

1998

Citation 

Carbohydrate Polymers, vol. 37, no. 0, pp. 13-18

Keywords 

MannofucogalactanFomitellan AMitogenic effectFomitella fraxinea

Abstract 

A heterogalactan, fomitellan A, was isolated from a 0.9% sodium chloride extract of the fruit bodies of Fomitella fraxinea by a combination of fractionation procedures, including precipitation with ethanol and chromatography on columns of DEAE-cellulose and Toyopearl HW 65F. On employing gel permeation-high performance liquid chromatograpy, fomitellan A exhibited a single peak with a molecular weight of 15 kDa. The results of methylation, and 1H and 13C NMR spectroscopic analyses indicated that the heterogalactan fomitellan A was a repeating unit (pentasaccharide) composed of a backbone with (1 → 6)-linked D-galactopyranosyl residues. Its C-2 atom position was substituted with disaccharide units of 3-O-D-mannopyranosyl-L-fucopyranosyl residues. The fucomannaogalactan (fomitellan A) from Fomitella fraxinea showed pronounced immunostimulating activity in an in vitro lymphocytes proliferation assay.

ISSN 

0144-8617

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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