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Title 

Cloning and sequence analysis of cDNAs encoding the heavy and light chain variable regions of a human monoclonal antibody with specificity for hepatitis B surface antigen

Authors 

Chun Jeih RyuHong Keun ChungHyo Jeong Hong

Publisher 

Elsevier

Issue Date 

1998

Citation 

Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1380, no. 2, pp. 151-155

Keywords 

Monoclonal antibodyAnti-HBsAg antibodyNucleotide sequenceAntibody diversity(Human)

Abstract 

We cloned and analyzed the cDNA sequences encoding the variable regions of a human monoclonal antibody (23HN) (γ I, κ) that binds to the common a antigenic determinant on hepatitis B surface antigen and its fine epitope is different from those of previously known mAbs with the same specificity. The heavy and light chain variable regions are the members of human heavy chain subgroup III and kappa light chain subgroup III, respectively, and are most homologous to human germline V(H) segment DP-50 and V3κ segment DPK-22, respectively.

ISSN 

0304-4165

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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