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Title 

Enhanced production of D-β-hydroxyisobutyric acid through strain improvement

Authors 

Chul Ho KimWon Kyoung HongIn Young LeeEui Sung ChoiSang Ki Rhee

Publisher 

Elsevier

Issue Date 

1999

Citation 

Journal of Biotechnology, vol. 69, no. 0, pp. 75-79

Keywords 

D-β-Hydroxyisobutyric acidCandida rugosaIsobutyric acid

Abstract 

The mutant strains of Candida rugosa were developed for enhanced enantioselective production of D(-)-β-hydroxyisobutyric acid (D-HIBA) from isobutyric acid (IBA). Three mutant strains, C. rugosa MME 1027, MME 1259 and MME 1559, which can not assimilate propionic acid, were screened. The molar conversion yield and D-HIBA productivity were compared in fed-batch cultivations of the mutant strains. The maximum D-HIBA concentration of 150 g l-1 with the highest molar conversion yield of 81.8% was achieved with the strain MME 1259, while the highest productivity of 1.1 g l-1 h-1 was obtained with the strain MME 1027.

ISSN 

0168-1656

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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