상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β-cells

Authors 

Ji Won YoonChang Soon YoonHye Won LimQ Q HuangYup KangKwang Ho PyunK HirasawaR S SherwinHee Sook Jun

Publisher 

American Association for the Advancement of Science

Issue Date 

1999

Citation 

Science, vol. 284, no. 5417, pp. 1183-1187

Keywords 

animal cellautoimmune diseaseinsulin dependent diabetes mellitusmousepancreas islet beta cellprotein expressiontransgenic mousediabetes mellitus, type 1gene expressionmice

Abstract 

Glutamic and decarboxylase (GAD) is a pancreatic β cell autoantigen in humans and nonobese diabetic (NOD) mice. β Cell-specific suppression of GAD expression in two lines of antisense GAD transgenic NOD mice prevented autoimmune diabetes, whereas persistent GAD expression in the β cells in the other four lines of antisense GAD transgenic NOD mice resulted in diabetes, similar to that seen in transgene-negative NOD mice. Complete suppression of β cell GAD expression blocked the generation of diabetogenic T cells and protected islet grafts from autoimmune injury. Thus, β cell-specific GAD expression is required for the development of autoimmune diabetes in NOD mice, and modulation of GAD might, therefore, have therapeutic value in type 1 diabetes.

ISSN 

0036-8075

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)