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Title 

Use of high culture pH for the decreased proteolysis of human parathylroid hormone secreted by Saccharomyces cerevisiae

Authors 

Gu Yong SongBong Hyun Chung

Publisher 

Springer Verlag (Germany)

Issue Date 

1999

Citation 

Biotechnology Letters, vol. 21, no. 0, pp. 57-60

Keywords 

human parathyroid hormoneculture pHproteolysisSaccharomyces cerevisiae

Abstract 

Human parathyroid hormone (hPTH) was expressed and secreted in Saccharomyces cerevisiae. In batch fermentations performed at pH = 5.6, 6.5, 7.2 and 7.5, optimal production of hPTH (12.1 mg/l) was obtained at pH 7.2 after 24 h of culture. At pH 5.6, most of secreted hPTH was degraded. Proteolysis of hPTH was significantly decreased by increasing the culture pH.

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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