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Title 

Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists

Authors 

Im Seon LeeKeun Young JungSei Ryang OhSi Hyung ParkKyung Seop AhnHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

1999

Citation 

Biological & Pharmaceutical Bulletin, vol. 22, no. 3, pp. 265-267

Keywords 

Schisandra chinensisplatelet activating factor antagonistdibenzocyclooctadienelignan

Abstract 

We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1 x 10-6 M) in this study.

ISSN 

0918-6158

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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