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Title 

Inhibition of human tumor growth by 2'-hydroxy-and 2'-benzoyloxycinnamaldehydes

Authors 

C W LeeDong Ho HongSang Bae HanS H ParkH K KimByoung-Mog KwonHwan Mook Kim

Publisher 

Georg Thieme Verlag

Issue Date 

1999

Citation 

Planta Medica, vol. 65, no. 3, pp. 263-266

Keywords 

2' benzoyloxycinnamaldehyde2' hydroxycinnamaldehydecancer inhibitionnonhumanhumanstumor cells, cultured

Abstract 

2'-Hydroxycinnamaldehyde (HCA) was isolated from Cinnamomum cassia Blume (Lauraceae) and 2'-benzoyloxycinnamaldehyde (BCA) was prepared by the reaction of HCA and benzoyl chloride. HCA and BCA strongly inhibited in vitro growth of 29 kinds of human cancer cells and in vivo growth of SW-620 human tumor xenograft without the loss of body weight in nude mice. HCA prevented adherence of SW-620 cells to the culture surface but did not inhibit oncogenic K-Ras processing, implying its antitumor mechanisms at the cellular level.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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