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Title 

The inhibitory effect of polysaccharides isolated from phellinus linteus on tumor growth and metastasis

Authors 

Sang Bae HanChang Woo LeeYoung Jin JeonNam Doo HongIck Dong YooKyu-Hwan YangHwan Mook Kim

Publisher 

Elsevier

Issue Date 

1999

Citation 

Immunopharmacology, vol. 41, no. 2, pp. 157-164

Keywords 

Phellinus linteusAdriamycinImmunochemotherapyTumor growthMetastasis

Abstract 

It was previously reported that polysaccharides (PL) isolated from Phellinus linteus strongly stimulated cell-mediated and humoral immunity. This study was undertaken to investigate the immunochemotherapeutic activity of PL against tumor growth and metastasis. PL alone significantly prolonged the survival rate of B16F10-implanted mice, inhibited tumor growth in NCI-H23-implanted nude mice, and reduced the frequency of pulmonary metastasis of B16F10 melanoma. Adriamycin significantly inhibited tumor growth, but only slightly inhibited metastasis. The combination therapy with PL and adriamycin was more effective in inhibiting tumor growth, but not metastasis. PL did not induce direct toxicity in cancer cells, which is characteristic of immunotherapeutics. In conclusion, PL might be of use in immunochemotherapy of cancer because of its effective activities on tumor growth and metastasis through the immunopotentiation of the patients without toxicity.

ISSN 

0162-3109

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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