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Title 

Plasma and hepatic cholesterol and hepatic activites of 3-hydroxy-3-methyl-glutaryl-CoA reductase and Acyl Coa: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids

Authors 

Song Hae BokSung Heui LeeYong Bok parkKi Hwan BaeKwang Hee SonTae Sook JeongMyung Sook Choi

Publisher 

American Society for Nutrition

Issue Date 

1999

Citation 

Journal of Nutrition, vol. 129, no. 6, pp. 1182-1185

Keywords 

hesperidinnaringinHMG-CoA reductaseACATtangerine peel extractrats

Abstract 

The cholesterol-lowering effects of tangerine peel extract and a mixture of two citrus flavonoids were tested. Male rats were fed a 1 g/100 g high- cholesterol diet for 42 d with supplements of either tangerine-peel extract or a mixture of naringin and hesperidin (0.5 g/100 g) to study the effects of plasma and hepatic lipids, hepatic enzyme activities, and the excretion of fecal neutral sterols. Both the tangerine-peel extract and mixture of two flavonoids significantly lowered the levels (mean ± SE) of plasma (2.44 ± 0.59 and 2.42 ± 0.31 mmol/L, vs. 3.80 ± 0.28 mmol/L, P < 0.05), hepatic cholesterol (0.143 ± 0.017 and 0.131 ± 0.010 mmol/g vs. 0.181 ± 0.003 mmol/g, P < 0.05), and hepatic triglycerides (0.069 ± 0.007 and 0.075 ± 0.006 mmol/g vs. 0.095 ± 0.002 mmol/g, P < 0.05) compared to those of the control. The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase (1565.0 ± 106.0 pmol · min-1 · mg protein-1 and 1783.0 ± 282 pmol · min-1 mg protein-1 vs. 2487.0 ± 210.0 pmol · min-1 · mg protein-1, P < 0.05) and acyl CoA: cholesterol O-acyltransferase (ACAT) activities (548.0 ± 65.0 and 615.0 ± 80.0 pmol · min-1 · mg protein-1 vs. 806.0 ± 105.0 pmol min-1 · mg protein-1, P < 0.05) were significantly lower in the experimental groups than in the control. These supplements also substantially reduced the excretion of fecal neutral sterols compared to the control (211.1 ± 26.7 and 208.2 ± 31.6 mg/d vs. 521.9 ± 53.9 mg/d). The inhibition of HMG-CoA reductase and ACAT activities resulting from the supplementation of either tangerine-peel extract or a combination of its bioflavonoids could account for the decrease in fecal neutral sterol that appears to compensate for the decreased cholesterol biosynthesis in the liver.

ISSN 

0022-3166

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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