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Title 

Uncarinic acids: phospholipase Cγ1 inhibitors from hooks of Uncaria rhynchophylla

Authors 

Ji Suk LeeMi Young YangHo Sup YeoJin Woong KimHyun Sun LeeJong Seog Ahn

Publisher 

Elsevier

Issue Date 

1999

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 9, no. 0, pp. 1429-1432

Keywords 

phospholipase c inhibitoruncaria rhynchophylla extractuncarinic acid auncarinic acid benzyme inhibitorsoleanolic acidphospholipase Cphospholipase C gamma

Abstract 

Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cγ1 with IC50 values of 3 5.66 and 44.55 μM, respectively.

ISSN 

0960-894X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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