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Title 

In vitro anticomplementary activity of hederagenin saponins isolated from roots of dipsacus asper

Authors 

Sei Ryang OhKeun Young JungKun Ho SonSi Hyung ParkIm Seon LeeKyung Seop AhnHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1999

Citation 

Archives of Pharmacal Research, vol. 22, no. 3, pp. 317-319

Keywords 

Anticomplementary activityHederageninHederagenin saponinsDipsacus asper

Abstract 

Anticomplementary activity of hederagenin and related saponins isolated from Dipsacus asper was investigated in vitro. HN saponin F (3) was most potent with IC50 value of 3.7×10-5 M followed by 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)- β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (8), 3-O-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (5), dipsacus saponin A (4), and hederagenin (1) on the classical pathway (CP) of complement system, while the saponins 3-5 did not show the inhibition of hemolysis and rather increase the hemolysis on the alternative pathway (AP). However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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