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Title 

Dykellic acid, a novel apoptosis inhibitor from Westerdykella multispora F50733

Authors 

Ho Jae LeeChoong Hwan LeeMyung Chul ChungHyo Kon ChunJoon Shick RheeYung Hee Kho

Publisher 

Elsevier

Issue Date 

1999

Citation 

Tetrahedron Letters, vol. 40, no. 38, pp. 6949-6950

Keywords 

2 pyrone derivativedykellic acidunclassified drugapoptosisdrug isolationhumanhuman cellleukemia cell linemetabolitemonocytic leukemia

Abstract 

A novel apoptosis inhibitor, dykellic acid (1), was isolated from the fermentation broth of Westerdykella multispora F50733. The structure of 1 was elucidated by spectral and X-ray crystallographic data. Compound 1 inhibited the etoposide-induced apoptosis of human monocytic leukemia U937 cells.

ISSN 

0040-4039

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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