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Title 

Isolation and charaterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase

Authors 

Mi Hui HongYong Hee LeeJae Wha KimJong-Seok LimSung Yeoul ChangKwang Soo LeeSang Gi PaikIn Seong Choe

Publisher 

International Union of Biochemistry and Molecular Biology

Issue Date 

1999

Citation 

Biochemistry and Molecular Biology International, vol. 47, no. 3, pp. 407-415

Keywords 

10-formyltetrahydrofolate dehydrogenase (10-FTHFDH)cDNAtissue distributionhuman

Abstract 

A cDNA clone encoding 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) was isolated from a human fetal liver cDNA library. It contained the open reading frame of 2709 base pairs and predicted a protein comprising 902 amino acids with a calculated molecular weight of 98,700 Da. The deduced protein showed about 93.6% homology (90.5% identity, 3.1% favored substitutions) when compared with rat 10-FTHFDH. The distribution of 10-FTHFDH transcript in various human tissues was studied by Northern blot analysis using poly(A+) RNAs from different tissues. The 10-FTHFDH transcript with an approximate size of 2.7 kb was mainly expressed in human kidney, skeletal muscle, and liver and rarely expressed in other tissues.

ISSN 

1039-9712

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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