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Title 

Cloning of the genomic sequence encoding a processed adenylate kinase 2 pseudogene

Authors 

Yong Hee LeeMi Hui HongYeon Jung KimJae Wha KimCheorl Ho KimKwang Soo LeeSung Yeoul ChangJong-Seok LimIn Seong Choe

Publisher 

International Union of Biochemistry and Molecular Biology

Issue Date 

1999

Citation 

Biochemistry and Molecular Biology International, vol. 47, no. 1, pp. 37-46

Keywords 

genomic sequenceAK2 processed pseudogenechromosomal locus

Abstract 

A chromosomal DNA sequence harboring a processed AK2B pseudogene was isolated from a human genomic library. It was a variant of the AK2B gene sequence including several point mutations, deletions, and insertions. The nucleotide sequence of the ORF of the AK2B pseudogene predicted a truncated form of the AK2B mutant suggesting that the processed pseudogene is nonfunctional. A repetitive sequence, AAAAGAGAG, found in the 5' and 3' flanking regions of the pseudogene and the poly(A) tract in the 3' end junction suggest that a mRNA of AK2B may have been converted to the processed pseudogene by retrotransposition events. Previously, it was suggested that an adenylate kinase (AK) 2 related gene on chromosome 2, confirmed by Southern analysis using somatic cell hybrid cell lines, may be a processed pseudogene. It is proposed that the processed pseudogene isolated in this study may be the AK2 related nonfunctional gene localized on human chromosomes 2.

ISSN 

1039-9712

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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