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Title 

Antitumor effects of IL-6 on murine liver tumor cells in vivo

Authors 

Hyung Sik KangDae Ho ChoSung Sook KimKwang Ho PyunIn Pyo Choi

Publisher 

Karger

Issue Date 

1999

Citation 

Journal of Biomedical Science, vol. 6, no. 2, pp. 142-144

Keywords 

Liver tumorInterleukin-6Antitumor effectsHost immunity

Abstract 

IL-6 is a pleiotropic cytokine that is capable of modulating the diverse functions of hepatocytes such as acute phase responses and inflammation in the liver. To learn its antitumor effects in vivo, the cDNA of IL-6 was transfected into murine liver cells, TIB cells. IL-6-transfected TIB cells (TIB73-IL-6 or TIB75-IL-6) produced much higher levels of IL-6 compared with vector-transfected TIB cells (TIB73-vec or TIB75-vec). To investigate the effects of IL-6 on TIB tumor growth in vivo, IL-6-transfected TIB cells or vector-transfected TIB cells were injected subcutaneously into syngeneic mice. Vector-transfected TIB cells grew rapidly 3 weeks after injection, but IL-6-transfected TIB cells did not grow at all for up to 6 weeks. Pathologically, IL-6-transfected TIB cells demonstrated a severe necrosis and apoptotic pattern. Taken together, these results indicate that IL-6 functions as a growth inhibiting factor in vivo, and another biological role of IL-6 in the liver is suggested.

ISSN 

1021-7770

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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