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Title 

Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum

Authors 

Dang Thi Lan HuongHee Cheol ChoiTae Cheol RhoHyun Sun LeeMyung Koo LeeYoung Ho Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1999

Citation 

Archives of Pharmacal Research, vol. 22, no. 3, pp. 324-326

Keywords 

Peucedanum japonicumUmbelliferaeCoumarinsMonoamine oxidase

Abstract 

Four coumarins were isolated from chloroform extract of the root of Peucedanum japonicum and identified as praeruptorin A (1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC50 values of them were shown to be 27.4 μM (1), 40.7 μM (2), 35.8 μM (3), and 13.8 μM (4), in vitro.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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