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Title 

Inhibition of nitric oxide production by coumarins from Peucedanum Japonicum in LPS-Activated RAW 264.7 cells

 

갯기름나물의 쿠마린에 의한 RAW 264.7 세포주의 Nitric oxide 생성 저해활성

Authors 

Hee Cheol ChoiTae Cheol RhoBo Yeon KimHack Ryong KoWon Keun OhChang Keun SeongTae Ick MheenJong Seog AhnHyun Sun Lee

Publisher 

Korean Society of Pharmacognosy

Issue Date 

1999

Citation 

Korean Journal of Pharmacognosy, vol. 30, no. 2, pp. 99-104

Keywords 

Peucedanum japonicumcoumarinsnitric oxideRAW 264.7 cellslipopolysaccharide (LPS), iNOS

Abstract 

During the screening for inhibitors of nitric oxide production in LPS- activated macrophage, RAW 264.7 cells. Five coumarins were isolated from chloroform extract of the root of Peucedanum japonicum. They were identified as praeruptorin A (1), xanthotoxin (2), psoralen (3), isopimpinellin (4), bergapten (5) on the basis of spectroscopic methods. The IC50 values for nitrite production by activated macrophages were about 1.5 μg/ml (1), 0.3 μg/ml (2), 1.0 μg/ml (3), 25 μg/ml (4), 25 μg/ml (5), respectively. However, the inducible nitric oxide synthase (iNOS) was not inhibited by treatment with these compounds. Their inhibitory effect on nitric oxide production was resulted from the suppression of iNOS expression.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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