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Title 

Protective antitumor activity through dendritic cell immunization is mediated by NK cell as well as CTL activation

Authors 

Kwang Dong KimJin Koo KimSe Jin KimIn Seong ChoeTai Wha ChungYong Kyung ChoeJong-Seok Lim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1999

Citation 

Archives of Pharmacal Research, vol. 22, no. 4, pp. 340-347

Keywords 

Dendritic cells (DCs)Colon tumorAntitumor immunitybone marrow cellcell culturelymphocyte activationnatural killer cell

Abstract 

Dendritic cells (DCs) are potent professional antigen-presenting cells (APC) capable of inducing the primary T cell response to antigen. Although tumor cells express target antigens, they are incapable of stimulating a tumor-specific immune response due to a defect in the costimulatory signal that is required for optimal activation of T cells. In this work, we describe a new approach using tumor-DC coculture to improve the antigen presenting capacity of tumor cells, which does not require a source of tumor-associated antigen. Immunization of a weakly immunogenic and progressive tumor cocultured with bone marrow-derived DCs generated an effective tumor vaccine. Immunization with the cocultured DCs was able to induce complete protective immunity against tumor challenges and was effective for the induction of tumor-specific CTL (cytotoxic T lymphocyte) activity. Furthermore, high NK cell activity was observed in mice in which tumors were rejected. In addition, immunization with tumor-pulsed DCs induced delayed tumor growth, but not tumor eradication in tumor-bearing mice. Our results demonstrate that coculture of DCs with tumors generated antitumor immunity due to the NK cell activation as well as tumor-specific T cell. This approach would be useful for designing tumor vaccines using DCs when the information about tumor antigens is limited.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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