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Title 

Acylated flavonol glycosides with anti-complement activity from Persicaria lapathifolia

Authors 

Si Hyung ParkSei Ryang OhKeun Young JungIm Seon LeeKyung Seop AhnJung Hee KimYoung Soo KimJung Joon LeeHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

1999

Citation 

Chemical & Pharmaceutical Bulletin, vol. 47, no. 10, pp. 1484-1486

Keywords 

Persicaria lapathifoliaanti-complement activitykaempferol 3-O-β-D- (6'-p-hydroxybenzoyl)-galactopyranosideQuercetin 3-O-β-D-(6'-feruloyl)- galactopyranosideQuercetin 3-O-β-D-(2'-galloyl)-rhamnopyranosideQuercetin 3-O-β-D-(2'-galloyl)-glucopyranoside

Abstract 

During a search for biologically active compounds from traditional medicines, a crude extract of Persicaria lapathifolia was found to have anti- complement activity. Bioassay-guided chromatographic separation of the active constituents led to the isolation of a new acylated kaempferol glycoside (1) and three known acylated quercetin glycosides (2 - 4). The structures of compounds 1 - 4 were characterized as kaempferol 3-O-β-D-(6'-p- hydroxybenzoyl)-galactopyranoside, quercetin 3-O-β-D-(6'-feruloyl)- galactopyranoside, quercetin 3-O-β-D-(2'-galloyl)-rhamnopyranoside and quercetin 3-O-β-D-(2'-galloyl)-glucopyranoside, respectively. Compounds 1 - 4 showed strong anti-complement activity (IC50 values of 4.3, 9.7, 3.9 and 7.6 x 10-5 M, respectively) on the classical pathway of the complement. On the other hand, six isolated flavonol glycosides (510) did not show any activity on this system.

ISSN 

0009-2363

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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