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Title 

Anti-helicobacter pylori activity of quinolone alkaloids from evodiae fructus

Authors 

Tae Cheol RhoEun Ah BaeDong Hyun KimWon Keun OhBo Yeon KimJong Seog AhnHyun Sun Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

1999

Citation 

Biological & Pharmaceutical Bulletin, vol. 22, no. 10, pp. 1141-1143

Keywords 

Helicobacter pyloriEvodia rutaecarpaQuinolone alkaloid

Abstract 

A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone alkaloids, evocarpine (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3), 1-methyl-2- undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl- 4(1H)-quinolone (6). They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 μg/ml. However, they had no effect on Helicobacter pylori urease activity at the concentration of 300 μg/ml.

ISSN 

0918-6158

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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