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Title 

Phospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba (2)

 

은행 종의의 Phospholipase Cγ1 저해 활성 성분 (2)

Authors 

Ji Suk LeeYou Sun ChoJin Woong KimHyun Sun LeeJong Seog Ahn

Publisher 

Korean Society of Pharmacognosy

Issue Date 

1999

Citation 

Korean Journal of Pharmacognosy, vol. 30, no. 3, pp. 280-283

Keywords 

Phospholipase Cγ1 (PLCγ1)Ginkgo biloba sarcotestasGinkgoaceae(3R)- (-)-8-hydroxy-3-(6'-pentadecenyl)-3,4-dihydroisocoumarin3-heptadecen-2-one

Abstract 

Using the bioassay-guided fractionation and isolation technique, two PLCγ1 inhibitors were isolated from the sarcotestas of Ginkgo biloba (Ginkgoaceae). The structures of these compounds were identified as (3R)-(-)- 8-hydroxy-3-(6'-pentadecenyl)-3,4-dihydroisocoumarin (1) and 3-heptadecen-2- one (2) by UV, IR, MS, 1H-NMR and H-13C COSY. Isolated compounds 1 and 2 have not been reported previously from the sarcotestas of G. biloba and Ginkgoaceae, respectively. In addition, these compounds showed significant PLCγ1 inhibitory effects with the IC50 of the 9.7 (1) and 25.6 μM (2).

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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