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Title 

Antibacterial activity of antimycotic miconazole against methicillin-resistant Staphylococcus aureus

Authors 

Sang Hwa LeeChang Jin Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

1999

Citation 

Journal of Microbiology and Biotechnology, vol. 9, no. 5, pp. 572-575

Keywords 

miconazoleantibacterial activityMRSAα-tocopherol

Abstract 

Miconazole was estimated to have a minimum inhibitory concentration of 0.78 μg/ml against the methicillin-resistant strains of Staphylococcus aureus (MRSA). The antibacterial activity of miconazole against MRSA was bacteriostatic in cation-adjusted Mueller-Hinton broth, but bacteriocidal in saline solution. The anti-MRSA activity of miconazole did not show a significant change under the susceptibility-testing conditions such as various inoculum sizes, pHs, or cations (Ca++ or Mg++) which was added to the medium. However, the anti-MRSA activity of miconazole was completely suppressed by lipophilic α-tocopherol (50 μg/ml), but definitely not by water-soluble ascorbic acid.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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