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Title 

Fatal measles virus infection in japanese macaques(Macaca fuscata)

Authors 

Yang Kyu ChoiM A SimonD Y KimB I YoonS W KwonK W LeeI B Seo

Publisher 

American College of Veterinary Pathologists

Issue Date 

1999

Citation 

Veterinary Pathology, vol. 36, no. 4, pp. 594-600

Keywords 

Candida albicanscytomegalovirusJapanese macaquesmeaslespneumonia

Abstract 

An outbreak of natural measles virus infection occurred in a group of Japanese macaques (Macaca fuscata). Over a period of 4 months, 12 of 53 Japanese macaques died following a 2-23-day history of anorexia, diarrhea, and dermatitis. The monkeys were kept in outdoor exhibits but had been moved temporarily into indoor caging and then transferred to new outdoor exhibits. Ten monkeys died while they were in temporary caging, and two monkeys died after they were moved to new outdoor exhibits. The diagnoses were made based on the results of histopathology, immunohistochemistry (IHC), in situ hybridization (ISH), and electron microscopy. Measles virus antigens were detected in the lung, stomach, skin, salivary gland, spleen, and lymph nodes. Tangled, tubular nucleocapsids compatible with paramyxovirus were noted in the lung tissue. As a result of immunosuppression following measles virus infection, various secondary infections including disseminated cytomegalovirus infection, adenoviral and bacterial pneumonia, and Candida albicans-associated gingivitis and esophagitis were noted. The primary infective source or the mode of infection could not be determined in this outbreak, but measles virus may have been transmitted to the monkeys from human visitors while the monkeys were on exhibit.

ISSN 

0300-9858

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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