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Title 

Sesquiterpene esters from celastrus orbiculatus and their structure-activity relationship on the modulation of multidrug resistance

Authors 

Se Eun KimHang Sub KimYoung Soo HongYoung Chang KimJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

1999

Citation 

Journal of Natural Products, vol. 62, no. 5, pp. 697-700

Keywords 

sesquiterpene derivativemultidrug resistancestructure activity relationdrug resistance, multipledrug resistance, neoplasmsesquiterpenesstructure-activity relationshipcelastrus orbiculatus

Abstract 

Six new (1-6) and three known (7-9) sesquiterpene esters were isolated from the roots of Celastrus orbiculatus. The structures of the new compounds were elucidated as 1β-acetoxy-6α-furoyloxy-9α-benzoyloxydihydro-β- agarofuran (1), 1β-acetoxy-6α-benzoyloxy-9α-furoyloxydihydro-β-agarofuran (2), 1β-acetoxy-6α,9α-difuroyloxydihydro-β-agarofuran (3), 1β,2β- diacetoxy-6α-furoyloxy-9α-benzoyloxydihydro-β-agarofuran (4), 1β- acetoxy-2β,6α-difuroyloxy-9α-benzoyloxydihydro-β-agarofuran (5), and 1β- acetoxy-2β,6α,9α-tribenzoyloxydihydro-β-agarofuran (6). Compounds 4, 5, and 7-9 were shown to be more active than verapamil in reversing vinblastine resistance in multidrug-resistant KB-V1 cells.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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