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Title 

α-glucosidase inhibitors from commelina communis

Authors 

Hang Sub KimYoung Ho KimYoung Soo HongNam Soo PaekHong Sub LeeTae Han KimKee Won KimJung Joon Lee

Publisher 

Georg Thieme Verlag

Issue Date 

1999

Citation 

Planta Medica, vol. 65, no. 0, pp. 437-439

Keywords 

alpha glucosidase inhibitorglucosidasealpha-glucosidasesenzyme inhibitorscommelina communis

Abstract 

A methanolic extract of Commelina communis showed potent inhibitory activity against α-glucosidase. One pyrrolidine alkaloid, 2,5- dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), α- homonojirimycin (4) and 7-O-β-D-glucopyranosyl α-homonojirimycin (5) were isolated by bioassay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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