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Title 

Pregnane glycoside multidrug-resistance modulators from cynanchum wilfordii

Authors 

Bang Yeon HwangSe Eun KimYoung Ho KimHang Sub KimYoung Soo HongJai Seup RoKyong Soon LeeJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

1999

Citation 

Journal of Natural Products, vol. 62, no. 4, pp. 640-643

Keywords 

multidrug resistancedrug resistance, multipledrug resistance, neoplasmcynanchum wilfordii

Abstract 

The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-β-D- cymaropyranosyl(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl- (1→4)-β-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 μM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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