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Title 

Isolation and characterization of a novel antifungal peptide from Aspergillus niger

Authors 

Dong Gun LeeSong Yub ShinCheol Young MaengZhe Zhu JinKil Lyong KimKyung Soo Hahm

Publisher 

Elsevier

Issue Date 

1999

Citation 

Biochemical and Biophysical Research Communications, vol. 263, no. 3, pp. 646-651

Keywords 

amino acidantifungal agentpeptidepolypeptideamino acid sequenceantibacterial activityarabidopsisaspergillusaspergillus nigerbacillus subtilis

Abstract 

A novel antifungal peptide (termed as Anafp) was isolated from the culture supernatant of the filamentous fungi, Aspergillus niger. The whole amino acid sequence of Anafp was determined and the peptide was found to be composed of a single polypeptide chain with 58 amino acids including six cysteine residues. The peptide shows some degree of sequence homology to a cysteine-rich antifungal peptides reported from the seeds of Sinapis alba and Arabidopsis thaliana or the extracellular media of Aspergillus giganteus and Penicillium chrysogenumsome. Cysteine-spacing pattern of Anafp was similar to that of the antifungal peptide from Penicillium chrysogenum. The Anafp exhibited potent growth inhibitory activities against yeast strains as well as filamentous fungi at a range from 4 to 15 μM. In contrast, Anafp did not show antibacterial activity against Echerichia coli and Bacillus subtilis even at 50 μM.

ISSN 

0006-291X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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