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Title 

Tylopeptins A and B, new antibiotic peptides from Tylopilus neofelleus

Authors 

Sang Jun LeeBong Sik YunDuck Hyun ChoIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

1999

Citation 

Journal of Antibiotics, vol. 52, no. 11, pp. 998-1006

Keywords 

amino acidpeptaibolpolypeptide antibiotic agenttylopeptin atylopeptin bunclassified drugacetylationamino terminal sequenceantibacterial activityantifungal activitycarbon nuclear magnetic resonance

Abstract 

Two new peptides, tylopeptins A and B, were isolated from the methanol extract of the fruiting body of the mushroom, Tylopilus neofelleus. These peptides were identified as peptaibols possessing an acetylated N-terminal residue, fourteen amino acids, and leucinol as the C-terminal amino alcohol. Sequential determination and complete 1H and 13C resonance assignments were based on positive ion FAB mass spectroscopy and two dimensional NMR techniques. These peptides were subsequently shown to be active against some Gram-positive bacteria, but inactive against pathogenic fungi and Gram-negative bacteria.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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