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Title 

An antibacterial compound against Pasteurella haemolytica produced by Streptomyces sp.

 

반추동물 급성기관지폐렴균 Pasteurella haemolytica에 항균활성을 갖는 물질의 특성규명

Authors 

Hee Chol KangIn Ja RyooBong Sik YunYong Soo JeonIck Dong Yoo

Publisher 

Korean Journal of Applied Microbiology and Biotechnology

Issue Date 

1999

Citation 

Korean Journal of Applied Microbiology & Biotechnology, vol. 27, no. 4, pp. 339-343

Keywords 

hygromycin APasteurella haemolyticastructure determinationantimicrobial activity

Abstract 

Pasteurella haemolytica is well known to cause severe pneumonia, consolidation and oedema of the lung, and fibrinous pleurisy under the stress and infection of virus in the cattle. In the course of our screening for antimicrobial agents against P. haemolytica, compound 51086 has been isolated from the fermentation broth of Streptomyces sp. 51086. The compound 51086 was purified by SiO2, Sephadex LH-20 and ODS column chromatographies and HPLC, subsequently. The structure of compound 51086 was determined as hygromycin A by combination of 1(H) NMR, 13(C) NMR, HMBC, and ESI-MS. This compound showed significant antibacterial activity against P. haemolytica and P. multocida.

ISSN 

0257-2389

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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