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Title 

Effects of retroviral-mediated Herpes Simplex Virus Thymidine Kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo

Authors 

Hyun Sang ChoYoung Nyun ParkChuhl Joo LyuChang Hyun YangKi Yang RyooByung Soo KimKir Young KimYeon Soo Kim

Publisher 

Taylor & Francis

Issue Date 

1999

Citation 

Acta Oncologica, vol. 38, no. 8, pp. 1093-1097

Keywords 

thymidine kinaseanimal cellgene therapygene transferHerpes simplex virusneuroblastoma cellgene expressiongene transfer techniquesgenetic vectorsneuroblastoma

Abstract 

Selective introduction of genes conferring chemosensitivity on proliferating tumor cells can be used to treat cancer. We investigated the efficacy of retrovirus-mediated gene transfer of the herpes simplex virus thymidine kinase (HSV-TK) gene to murine neuroblstoma cell lines [neuro-2a) in vitro and in vivo. Retrovirus-mediated HSV-TK gene transfer to the neuro- 2a cells resulted in sensitivity to ganciclovir (GCV) in vitro. In A/J mice, tumors produced from HSV-TK transduced neuro-2a cells regressed after GCV treatment. Intratumoral injection of recombinant retrovirus expressing HSV-TK gene also inhibited growth of the tumor established in A/J mice. These results demonstrate that HSV-TK gene therapy might be a feasible approach for inhibiting the growth of neuroblastoma.

ISSN 

0284-186X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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