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Title 

5-methylmellein and nectriapyrone, two new monoamine oxidase inhibitors

Authors 

In Kyoung LeeBong Sik YunSei Kwan OhYoung Ho KimMyung Koo LeeIck Dong Yoo

Issue Date 

1999

Citation 

Medical Science Research, vol. 27, no. 0, pp. 463-465

Keywords 

fungi5-methylmelleinmonoamine oxidase nectriapyronephytotoxin

Abstract 

In the course of screening for monoamine oxidase (MAO) inhibitors among microbial metabolites, we found that unidentified fungal strain 8082 produced 5-methylmellein, which slows potent inhibitory activity against mouse brain MAO. Although, 5-methylmellein has been previously isolated as a phytotoxin, its MAO inhibitory activity has not hitherto been reported. During the purification of 5-methylmellein, we also isolated nectriapyrone as a minor component. Nectriapyrone has not been previously reported as MAO inhibitor either. We describe the inhibitory activities of 5-methylmellein and nectriapyrone on MAO. 5-Methylmellein and nectriapyrone inhibited MAO in a dose-dependent manner and their IC50 values were 1.06 and 8.9 μM respectively.

ISSN 

0269-8951

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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