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Title 

HIV integrase inhibitory activity of Agastache rugosa

Authors 

Hye Kyong KimHyeong Kyu LeeCha Gyun ShinHoon Huh

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1999

Citation 

Archives of Pharmacal Research, vol. 22, no. 5, pp. 520-523

Keywords 

HIV integraseAgastache rugosaLabiataeRosmarinic acid

Abstract 

We have been screening anti-HIV integrase compounds from Korean medicinal plants by using an in vitro assay system which is mainly composed of recombinant human immunodeficency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots of Agastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The IC50 of the rosmarinic acid was approximately 10 μg/ml against HIV integrase.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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