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Title 

Gene expression of neuroD/BETA2 during development of the mouse central nervous system

 

생쥐 중추신경계에서 NeuroD/BETA2 유전자의 발현

Authors 

Jang Hyeon ChoWoo Sup HwangYeon Soo KimYoung Don LeeHae Young Suh-Kim

Issue Date 

2000

Citation 

Korean Journal of Anatomy, vol. 33, no. 1, pp. 13-19

Keywords 

neuroDBETA2brainmouse

Abstract 

NeuroD/BETA2, a basic helix-loop-helix transcription factor, has been known to play a role in terminal differentiation during neurogenesis. To gain further insight into the function of NeuroD/BETA2 in the nervous system development, we examined the expression pattern of NeuroD/BETA2 during embryonic and postnatal development by in situ hybridization. Dynamic changes of NeuroD/BETA2 expression were observed in the developing nervous system. Gene expression of the NeuroD/BETA2 in developing cerebellum and hippocampus increased during the embryonic stages and persisted throughout postnatal development and remained at a stable level in the adult brain. NeuroD/BETA2 expression was detected in postmitotic cells in the subventricular zone of the cerebrum during embryogenesis. This observation confirms that NeuroD/BETA2 may have a role in terminal differentiation during neurogenesis.

ISSN 

1225-1305

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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