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Title 

Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii

Authors 

Bong Sik YunIn Kyoung LeeJong Pyung KimIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2000

Citation 

Journal of Antibiotics, vol. 53, no. 2, pp. 114-122

Keywords 

alpha tocopherolbutylated hydroxyanisolecaffeic acidcatechincurtisian acurtisian bcurtisian ccurtisian dscavengerunclassified drug

Abstract 

In our continuous investigation for free radical scavengers from extracts of fruit body of basidiomycetes, we have isolated four new p-terphenyl compounds, designated as curtisians A~D, from the methanolic extract of the fruit body of Paxillus curtisii. These compounds were isolated by silica gel and Sephadex LH-20 column chromatographies, preparative-TLC and HPLC, consecutively. The structures of curtisians were assigned as p-terphanyls with substituents of acetyl, benzoyl, phenylbutyryl, 3-hydroxybutyryl and 3-acetoxybutyryl. Curtisians A, B, C and D exhibited inhibitory activity against lipid peroxidation with IC50 values of 0.15, 0.17, 0.24 and 0.14 μg/ml, respectively.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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