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Title 

TGF-β-induced cell-cycle arrest through the p21waf1/cip1_G1 cyclin/CDKS-p130 pathway in gastric-carcinoma cells

Authors 

Y D YooJu Youn ChoiSu Jae LeeJun S KimByung Re MinYoung Ik LeeYoon Koo Kang

Publisher 

Wiley-Blackwell

Issue Date 

1999

Citation 

International Journal of Cancer, vol. 83, no. 4, pp. 512-517

Keywords 

cyclinecell cyclehuman cellstomach carcinomacarcinomacyclin-dependent kinase inhibitor p21cyclin-dependent kinasescyclinsG1 phase

Abstract 

Transforming growth factor-β1 (TGF-β) inhibits cell-cycle progression of many types of cells by arresting them in G1/S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastric-cancer cells, SNU16, TGF-β treatment induced enhanced expression of p21(WAF1/CIP1) (p21), which inhibited the kinase activity of cyclin-D- and cyclin-E-associated Cdks and blocked p130 phosphorylation. TGF-β also enhanced the stability of p130, suggesting that hypophosphorylation of p130 and increased stability of p130 contribute to p130-mediated G arrest in gastric-cancer cells. Our results demonstrate that p21 and p130 are major downstream targets of TGF-β in gastric-cancer cells and that a p21-G1 cyclin/Cdks-p130/E2F pathway mediates growth inhibition by TGF-β in these cells.

ISSN 

0020-7136

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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