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Title | Antimicrobial activity of 9-O-Acyl- and 9-O-Benzoyl-substituted berberrubines |
Authors | Sung Han Kim; Jung Ae Jeun; Sang Jun Lee; Sung Uk Kim; Jung Han Kim |
Publisher | Georg Thieme Verlag |
Issue Date | 2000 |
Citation | Planta Medica, vol. 66, no. 4, pp. 361-363 |
Keywords | alkaloid; antibiotic agent; beroline; antimicrobial activity; drug isolation; gram positive bacterium; minimum inhibitory concentration; nonhuman; structure activity relation; microbial sensitivity tests |
Abstract | In the course of a structure-activity relationship study on berberrubine derivatives, a series of compounds bearing 9-O-acyl- (4-6) and 9-O-benzoyl- (7) substituents was synthesized with the expectation of increasing the antimicrobial activity. One of the berberrubine derivatives, 9- lauroylberberrubine chloride was the most active against Gram-positive bacteria Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis as well as the Gram- negative bacterium Klebsiella pneumoniae in comparison to berberine, the currently used antibiotic in clinic. This result suggested that the presence of lipophilic substituents of certain structures and sizes might be crucial for the optimal antimicrobial activity. |
ISSN | 0032-0943 |
Appears in Collections | |
Registered Date |
2019-05-02 |
