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Title 

Antimicrobial activity of 9-O-Acyl- and 9-O-Benzoyl-substituted berberrubines

Authors 

Sung Han KimJung Ae JeunSang Jun LeeSung Uk KimJung Han Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2000

Citation 

Planta Medica, vol. 66, no. 4, pp. 361-363

Keywords 

alkaloidantibiotic agentberolineantimicrobial activitydrug isolationgram positive bacteriumminimum inhibitory concentrationnonhumanstructure activity relationmicrobial sensitivity tests

Abstract 

In the course of a structure-activity relationship study on berberrubine derivatives, a series of compounds bearing 9-O-acyl- (4-6) and 9-O-benzoyl- (7) substituents was synthesized with the expectation of increasing the antimicrobial activity. One of the berberrubine derivatives, 9- lauroylberberrubine chloride was the most active against Gram-positive bacteria Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis as well as the Gram- negative bacterium Klebsiella pneumoniae in comparison to berberine, the currently used antibiotic in clinic. This result suggested that the presence of lipophilic substituents of certain structures and sizes might be crucial for the optimal antimicrobial activity.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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