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Title 

Sesquiterpene lactones, inhibitors of farnesyl protein transferase, isolated from the flower of Artemisia sylvatica

Authors 

Seung Ho leeHyun Mi KangHo Chul SongHee Soon LeeUn Chul LeeKwang Hee SonSung Hoon KimByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2000

Citation 

Tetrahedron, vol. 56, no. 27, pp. 4711-4715

Keywords 

artemisia sylvaticafarnesyl proteinsesquiterpene lactonesprotein farnesyltransferasesesquiterpene lactoneartemisia

Abstract 

Five sesquiterpene lactones, 8-acetylarteminolide (1), artanomaloide (2), arteminones (3 and 4), and dehydromatricarin (5), were isolated from the methanolic extract of the flower of Artemisia sylvatica and characterized on the basis of their spectral data. New sesquiterpene lactone 1 was identified as a configurational isomer of artanomaloide (2), and the new arteminones 3 and 4 are determined as stereoisomers. 8-Acetylarteminolide (1) strongly inhibited FPTase with an IC50 of 1.8 μM, however, the other sesquiterpene lactones mildly inhibited the transferase with an IC50 of 22-300 μM.

ISSN 

0040-4020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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