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Title 

Chaetoatrosin A, a novel chitin synthase II inhibitor produced by Chaetomium atrobrunneum F449

Authors 

Eui Il HwangBong Sik YunYoung Kook KimByoung-Mog KwonHong Gi KimHyang Bok LeeKyung Sook BaeSung Uk Kim

Publisher 

Nature Publishing Group

Issue Date 

2000

Citation 

Journal of Antibiotics, vol. 53, no. 3, pp. 248-255

Keywords 

chaetoatrosin achitin synthaseenzyme inhibitorunclassified drugantifungal activitybotrytis cinereacarbon nuclear magnetic resonancechaetomiumchromatographyconcentration response

Abstract 

Chaetoatrosin A, a novel chitin synthase II inhibitor, was isolated from the culture broth of fungus F449, which was identified as Chaetomium atrobrunneum F449. Chaetoatrosin A was purified by solvent partition, silica gel, ODS, preparative TLC, and Sephadex LH-20 column chromatographies, consecutively. The structure of chaetoatrosin A was assigned as 1,8-dihydroxy-3(2-hydroxypropionyl)-6-methoxynaphthalene on the basis of various spectroscopic analyses including UV, IR, mass spectral, and NMR. Its molecular weight and formula were found to be 262 and C14H14O5, respectively. Chaetoatrosin A inhibited chitin synthase II by 50% at the concentration of 104 μg/ml in an enzyme assay system. This compound showed antifungal activities against Rhizoctonia solani, Pyricularia oryzae, Botrytis cinerea, Cryptococcus neoformans and Trichophyton mentagrophytes.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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